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(Circulation. 1971;43:528.)
© 1971 American Heart Association, Inc.

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Effects of Isoproterenol on the Pulmonary Circulation in Patients with Chronic Obstructive Lung Disease

M. IRENÉ FERRER M.D.¹; YALE ENSON M.D.¹; MARGARET M. KILCOYNE M.D.¹; RÉJANE M. HARVEY M.D.¹

¹ From the Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York.

Isoproterenol produced an increase in pulmonary blood volume and pulmonary blood flow without a significant change in pulmonary vascular pressures in 14 patients with obstructive lung disease, six of whom had cor pulmonale. These findings are consistent with a vasodilating effect on the pulmonary vasculature. Evidence is presented that muscular pulmonary arteries constricted by hypoxia were affected by the drug. There is little to suggest that the compliance of the elastic arteries was altered by isoproterenol.

Key Words: Cor pulmonale • Pulmonary vasodilatation • Pulmonary arterial compliance • Pulmonary blood volume

Submitted on July 16, 1970
Accepted on December 17, 1970