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(Circulation. 1971;43:I-51.)
© 1971 American Heart Association, Inc.

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Lipids in Silicone Rubber Valve Prostheses After Human Implantation

H. P. CHIN PH.D.¹; EARL C. HARRISON M.D.¹; DAVID H. BLANKENHORN M.D.¹; JOVAN MOACANIN PH.D.¹

¹ From the University of Southern California School of Medicine, Los Angeles, and the Jet Propulsion Laboratory, Polymer Research Section, Pasadena, California.

Fourteen prosthetic valves were obtained from human recipients at autopsy or valve replacement surgery. The silicone rubber poppets were extracted with lipid solvent and examined by thin-layer chromatography, infrared absorption spectroscopy, and phosphorus analysis. The significant findings were: (1) No phospholipid was present in any of the valves; neither was there any protein. (2) The relative content of cholesterol, cholesteryl ester, fatty acid, and triglyceride varied widely. (3) Residual uncured silicone polymers were found in all valves; in one patient these appeared to combine with lipid and form a component with unusual chromatographic behavior.

Key Words: Valve variance • Uncured silicone polymers • phospholipid