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(Circulation. 1971;44:174.)
© 1971 American Heart Association, Inc.

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Combined Papillary Muscle and Left Ventricular Wall Dysfunction as a Cause of Mitral Regurgitation

An Experimental Study

ARUN K. MITTAL M.D.¹; MANLY LANGSTON JR. M.D.¹; KEITH E. COHN M.D.¹; ARTHUR SELZER M.D.¹; WILLIAM J. KERTH M.D.¹

¹ From the Departments of Cardiovascular Surgery and Cardiology of the Heart Research Institute, the Institute of Medical Sciences, and Presbyterian Hospital, Pacific Medical Center, San Francisco, California.

Papillary muscle infarction was produced in 16 mongrel dogs by placing sutures around the base of one of the papillary muscles. In addition, patchy infarction of the adjacent left ventricular wall was produced by placing an Ameroid constrictor around the appropriate coronary artery. Mitral insufficiency developed in 14 of these animals; it was severe in four and mild to moderate in ten. Mitral insufficiency was not produced by isolated infarction of a papillary muscle or by isolated infarction of the left ventricular wall.

It is concluded that papillary muscle infarction alone does not lead to mitral regurgitation, but that papillary; muscle dysfunction acts in concert with left ventricular wall dyskinesia or dilatation to produce mitral valve incompetency.

Key Words: Cardiac performance • Coronary disease • Myocardial infarction • Valve disease

Submitted on November 12, 1970
Accepted on April 2, 1971

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