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(Circulation. 1972;45:571.)
© 1972 American Heart Association, Inc.

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Combined Therapy with Vasodilator Drugs and Beta-Adrenergic Blockade in Hypertension

A Comparative Study of Minoxidil and Hydralazine

THOMAS B. GOTTLIEB M.D.¹; FRED H. KATZ M.D.¹; CHARLES A. CHIDSEY III M.D.¹

¹ From the Department of Medicine, University of Colorado Medical Center, Denver, Colorado.

The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy.

Control supine blood pressure fell from 191/128 mm Hg on propranolol and hydrochlorothiazide to 169/108 mm Hg on hydralazine, with a significantly greater reduction to 142/92 mm Hg on minoxidil. Although sodium retention and tachycardia were controlled by the use of concomitant diuretics and beta-blockade, an increment in each of these drugs was occasionally required to prevent these complications. Renal function was changed little with the decrease in blood pressure. Plasma renin increased from a standing control of 14.5 mµg/ml/hr to 35.9 and 31.1 mµg/ml/hr, respectively, on hydralazine and minoxidil. These data suggest the role of vasodilators used in combination with beta-blockers and diuretics and indicate the greater therapeutic efficacy of minoxidil.

Key Words: Antihypertensive therapy • Propranolol • Renin • Aldosterone

Submitted on August 6, 1971
Accepted on October 21, 1971

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