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(Circulation. 1973;47:1049.)
© 1973 American Heart Association, Inc.

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Quantitative Radionuclide Angiocardiography

Determination of Qp : Qs in Children

DAVID L. MALTZ M.D.¹ S. TREVES M.D.¹

¹ From the Departments of Cardiology and Radiology, The Children's Hospital Medical Center and the Departments of Pediatrics and Radiology, Harvard Medical School, Boston, Massachusetts.

A new method of determining pulmonary-to-systemic flow ratios (Qp/Qs) in patients with left-to-right shunts using radionuclide angiocardiography is described. It involves the analysis of pulmonary time-activity histograms using a gamma-variate model. It appears to be simple, relatively atraumatic, and superior to the methods using C₂/C₁ ratios because, in addition to accurately detecting the presence of left-to-right shunts, it permits precise quantitation. In the 35 patients studied, it was found that Qp/Qs <1.2 could be separated from Qp/Qs > 1.2 and that when the Qp/Qs is between 1.2 and <3 the shunts could be accurately quantified.

Key Words: Left-to-right shunt • Gamma variate • Ventricular septal defects • Radionuclide angiocardiography • Atrial septal defects • Ejection fractions

Submitted on July 6, 1972
Accepted on December 19, 1972

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