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(Circulation. 1973;48:179.)
© 1973 American Heart Association, Inc.

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Vitamin E and Its Relation to Heart Disease

ROBERT E. OLSON M.D.¹

¹ From the Department of Biochemistry, St. Louis University School of Medicine, St. Louis, Missouri.

Although vitamin E deficiency in ruminants results in conspicuous heart disease, a similar deficiency state in primates appears to spare the heart, even when other systems are affected. No heart disease in man has been related to a vitamin E deficiency. The pharmacologic use of vitamin E in doses 10 to 50 times the daily requirement was recommended in 1947 for the treatment of a variety of cardiovascular disorders, including intermittent claudication, angina pectoris, coronary occlusion, congestive heart failure, thrombophlebitis and thromboembolism, but no evidence of its effectiveness has been convincingly verified during the ensuing 25 years.

Key Words: Vitamin E • Intermittent claudication • Thrombophlebitis • Cardiovascular disease • Angina pectoris • Thromboembolism • Myocardial infarction • Coronary occlusion • Myocarditis • Congestive heart failure

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