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(Circulation. 1973;48:III-37.)
© 1973 American Heart Association, Inc.

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Infective Endocarditis in Drug Addicts

Experiences with Medical and Surgical Treatment

DAVID Y. GRAHAM M.D.¹; GEORGE J. REUL M.D.¹; RUSSELL MARTIN M.D.¹; JEREMY MORTON M.D.¹; JOHN H. KENNEDY M.D.¹

¹ From the Departments of Medicine and Surgery, Ben Taub General Hospital and Baylor College of Medicine, Houston, Texas.

Isolated tricuspid valvular endocarditis is no longer rare, and its increasing incidence has paralleled the rise in heroin addiction. In the period between December, 1969 and December, 1971, 16 episodes of bacterial endocarditis occurred in 13 individual drug abusers at the Ben Taub General Hospital, Houston. The tricuspid valve (TV) was involved in all cases. Two patients required surgery during the acute infection; one underwent total excision of the TV without replacement, and one received aortic and TV prostheses because of progressive heart failure. Antibiotic therapy was individualized and guided by tube dilution sensitivities and serum bactericidal levels. In view of the excellent response to antibiotic therapy, surgery for infected prosthetic or natural valves is presently reserved for those patients with progressive cardiac failure or infections unresponsive to medical therapy.

Key Words: Endocarditis • Tricuspid valvulectomy • Drug addiction • Tricuspid valve