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(Circulation. 1973;48:463.)
© 1973 American Heart Association, Inc.

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Function of Cardiac Receptors

R. J. LINDEN M.B., CH.B., M.R.C.P., PH.D., D.SC.¹

¹ From the Cardiovascular Unit, University of Leeds, The General Infirmary and Killingbeck Hospital, Leeds, England.

Stimulation of right and left atrial receptors causes an increase in activity in sympathetic nerves [see table in the PDF file] to the sinoatrial node resulting in 1) an increase in heart rate, 2) a decrease in activity in nerves to the kidney, with an unknown effect, and 3) a diuresis caused by a blood-borne agent which is said by others to be a reduction in the concentration of antidiuretic hormone.

This exciting finding leaves us with many questions both pure and applied. One may be important to us now. Remembering that these receptors have been vividly demonstrated in the atria of man should we not ask, Are these two small chambers not more important in man than commonly appreciated?

Key Words: Vagal nerves • Ventricles • Heart rate • Sympathetic nerves • Atrio-venous junction • Contractility • Urine flow • Nerve endings • Stretch receptors • Acidosis • Nerve discharge • Afferent fibers • Peripheral circulation • Atria • Efferent fibers

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