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(Circulation. 1973;48:797.)
© 1973 American Heart Association, Inc.

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The Role of Glucagon Hypersecretion in the Pathogenesis of Hyperglycemia Following Acute Myocardial Infarction

SHLOMO LANIADO M.D.¹; PESACH SEGAL M.D.¹; BARRY ESRIG M.D.¹

¹ From the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, and the Department of Medicine, Mount Sinai School of Medicine, New York, New York.

In a group of nondiabetic patients, postinfarction hyperglycemia was found to be closely associated with high levels of plasma immunoreactive glucagon (IRG).

It is proposed that, in certain cases, hyperglycemia following acute myocardial infarction may be related to a temporary and uninhibited rise in plasma glucagon levels, probably stimulated by the major stress of acute myocardial infarction.

Key Words: Growth hormone • Insulin

Submitted on January 15, 1973
Accepted on May 24, 1973