This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by DONNELLY, R. J. Articles by WATSON, D. A. Search for Related Content PubMed PubMed Citation Articles by DONNELLY, R. J. Articles by WATSON, D. A.

(Circulation. 1973;48:823.)
© 1973 American Heart Association, Inc.

---

Chronic Hemolysis Following Mitral Valve Replacement

A Comparison of the Frame-Mounted Aortic Homograft and the Composite Seat Starr-Edwards Prosthesis

R. J. DONNELLY M.B., F.R.C.S.E.¹; A. N. RAHMAN M.B.B.S.¹; S. M. MANOHITHARAJAH M.B., M.R.C.P., M.R.C.P.E.¹; P. B. DEVERALL M.B., F.R.C.S.¹; D. A. WATSON M.B., F.R.C.S.¹

¹ From the Leeds Regional Thoracic Surgical Centre and Department of Haematology, Killingbeck Hospital, Leeds, England.

The incidence and severity of chronic intravascular hemolysis was evaluated in a total of 41 patients following mitral valve replacement. Valve replacement was with a gamma-radiated frame-mounted aortic homograft in 21 patients and with a composite seat Starr-Edwards prosthesis, model 6310 or 6320, in 20 patients. The parameters used to assess hemolysis were hemoglobin, hematocrit, reticulocyte count, red cell fragment count, serum haptoglobin, LDH and HBD, hemosiderin in the urine and red cell survival. The degree of hemolysis was classified as mild, moderate or severe. In the prosthetic valve group 85% showed evidence of chronic intravascular hemolysis, of which a third were mild and the rest moderate. The homograft patients did not show any comparable evidence of hemolysis. Statistical analysis of the comparative figures of the parameters used to assess hemolysis in the two groups of patients revealed a significant difference (P < 0.01) in hemoglobin and hematocrit and a highly significant difference (P < .001) in serum haptoglobins, hemosiderin in the urine, LDH, reticulocyte count, red cell fragment count and red cell survivals.

Key Words: Cardiac hemolytic anemia • Hemosiderinuria • Haptoglobin • Frame-mounted homograft valves • Lactic dehydrogenase • Red cell survival

Submitted on April 9, 1973
Accepted on May 17, 1973

This article has been cited by other articles:

				A. Khanna, R. Tandon, A.K. Basu, and S. Shrivastava Red Blood Cell Survival in Patients with Ventricular Septal Defect and Patent Ductus Arteriosus Clinical Pediatrics, May 1, 1981; 20(5): 349 - 353. [Abstract] [PDF]