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(Circulation. 1973;48:936.)
© 1973 American Heart Association, Inc.

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Ischemic Response to Sudden Strenuous Exercise in Healthy Men

R. JAMES BARNARD PH.D.¹; REX MACALPIN M.D.¹; ALBERT A. KATTUS M.D.¹; GERALD D. BUCKBERG M.D.¹

¹ From the Departments of Medicine and Surgery, UCLA School of Medicine, Los Angeles, California.

In ten healthy, asymptomatic men, intra-arterial pressure and electrocardiograms were recorded during various types of exercise. Potential subendocardial blood flow was estimated from a diastolic pressure time index (DPTI) and myocardial oxygen requirements estimated from the tension time index (TTI). The ratio DPTI/TTI provided an estimate of the supply/demand relationship With sudden vigorous exercise without warm-up, the DPTI/TTI was below 0.35 in three men who had ischemic electrocardiograms, below 0.44 in three men with minor ST abnormalities, and above 0.44 in four men with normal ST segments. With a prior warm-up exercise, sudden exercise caused no ischemic changes, but DPTI/TTI was below 0.44 in two subjects who had minor ST abnormalities. Maximum treadmill testing produced higher heart rates and TTI than did sudden exercise, but DPTI/TTI was above 0.44 in all cases and no ST abnormalities occurred.

Abnormal electrocardiographic responses produced by sudden, vigorous exercise in normal men may represent subendocardial ischemia caused by a transient, unfavorable alteration in the subendocardial oxygen supply/demand relationship which is predictable from arterial pressure measurements.

Key Words: Treadmill test • Diastolic pressure time index • Tension time index

Submitted on March 19, 1973
Accepted on June 21, 1973

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