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(Circulation. 1973;48:943.)
© 1973 American Heart Association, Inc.

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Hemodynamic Determinants of Maximal Oxygen Intake in Patients with Healed Myocardial Infarction: Influence of Physical Training

MICHEL F. ROUSSEAU M.D.¹; LUCIEN A. BRASSEUR M.D.¹; JEAN-MARIE R. DETRY M.D.¹

¹ From the Cardio-Pulmonary Laboratory, Department of Medicine, University of Louvain, Belgium.

Fourteen patients with a healed myocardial infarction (no angina pectoris) had maximal oxygen intake (V_OO2 max) determinations and hemodynamic studies at submaximal and maximal exercise levels; seven patients were studied two months after an acute myocardial infarction (untrained group) while seven had followed a physical training program for 13.5 months (trained group). At the maximal exercise level, all patients exhibited a fall in stroke volume which was 15% (untrained group) and 18% (trained group) lower than at submaximal exercise level: this decrease in stroke volume, presumably resulting from myocardial ischemia, was the major factor limiting the V_oo2 max of the patients. The maximal arteriovenous oxygen (A-V_OO2) difference of untrained patients was the same (14.4 ml/100 ml) as for healthy subjects.

Higher V_OO2 max of trained patients (2.50 vs 2.07 liters/min) resulted almost exclusively from greater maximal A-V_OO2 difference (16.5 vs 14.4 ml/100 ml); this suggests that long-term physical training increases peripheral extraction of oxygen by the working muscles.

Key Words: Hemodynamic study • Stroke volume • Maximal cardiac output • Maximal arteriovenous oxygen difference

Submitted on March 16, 1973
Accepted on July 3, 1973

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