This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by COX, J. L. Articles by BOINEAU, J. P. Search for Related Content PubMed PubMed Citation Articles by COX, J. L. Articles by BOINEAU, J. P.

(Circulation. 1973;48:971.)
© 1973 American Heart Association, Inc.

---

The Electrophysiologic Time-Course of Acute Myocardial Ischemia and the Effects of Early Coronary Artery Reperfusion

JIMMY L. COX M.D.¹; THOMAS M. DANIEL M.D.¹; JOHN P. BOINEAU M.D.¹

¹ From the Departments of Surgery, Internal Medicine, and Pediatrics, Duke University Medical School, Durham, North Carolina.

Bipolar potentials were recorded from intramural electrodes located within areas of acute myocardial ischemia in dogs. Alterations in bipolar potential electromotive force (EMF) and local activation times were measured at predetermined intervals up to 12 hours after coronary occlusion. Histochemical stains were used to correlate structural-biochemical changes with sites of electrophysiologic changes. In severely ischemic areas, bipolar potentials lost 50% of their preocclusion EMF within 30 min and 95% within six hours at which time all parameters stabilized. Lesser decreases in bipolar potential EMF were recorded in the peripheral areas of the infarct. Bipolar potential EMF increased at the junction of ischemic and normal myocardium. Activation time was delayed in ischemic areas but no correlation between the magnitude of delay and the degree of tissue ischemia could be established. Coronary reperfusion after 30 min, one hr, two hr and six hr of occlusion resulted in some return in bipolar potential EMF, decreasing as a function of duration between occlusion and reperfusion.

Variation in the degree of ischemia of different zones of injury within an acute myocardial infarction, as well as a different response of those zones to the return of blood flow, was shown.

Key Words: Bipolar potential • Histochemical enzyme stains • Intramural electrodes • Parietal Purkinje system • Purkinje activation • Ventricular activation time

Submitted on January 16, 1973
Accepted on July 21, 1973

This article has been cited by other articles:

				K. Yamamoto and S. Bando Effects of Verapamil and Magnesium Sulfate on Electrophysiologic Changes During Acute Myocardial Ischemia and Following Reperfusion in Dogs: Comparative Effects of Administration by Intravenous and Coronary Sinus Retroperfusion Routes Angiology, June 1, 1996; 47(6): 557 - 568. [Abstract] [PDF]

				R. E. RUDE, J. E. MULLER, and B. EUGENE Efforts to Limit the Size of Myocardial Infarcts Ann Intern Med, December 1, 1981; 95(6): 736 - 761. [Abstract] [PDF]