This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by STEELE, P. P. Articles by GENTON, E. Search for Related Content PubMed PubMed Citation Articles by STEELE, P. P. Articles by GENTON, E.

(Circulation. 1973;48:1194.)
© 1973 American Heart Association, Inc.

---

Platelet Function Studies in Coronary Artery Disease

PETER P. STEELE M.D.¹; HUGH S. WEILY M.D.¹; HYWEL DAVIES M.D.¹; EDWARD GENTON M.D.¹

¹ From the Division of Cardiology, Department of Medicine, Denver Veterans Administration Hospital and the University of Colorado Medical Center, Denver, Colorado.

Platelets have been implicated and abnormal platelet function proposed in the pathogenesis of coronary artery disease (CAD). This investigation examines platelet function in men with stable, arteriographically defined CAD and correlates results with lipid pattern, history of angina or myocardial infarction and smoking habits. Platelet survival (⁵¹Chromium method), adhesiveness, and aggregation were measured in 21 men with CAD. Twelve patients had Type IV hyperlipoproteinemia and nine patients had normal lipoprotein level. Eighteen had angina and 13 had had infarction.

The average platelet survival for the total group was normal (6.8 ± 0.24 days, avg ± sem), but survival was shortened in 11 and normal in ten. There was no significant difference between: (1) patients with hyperlipoproteinemia (6.8 ± 0.30 days) and those with normal lipoproteins (6.9 ± 0.41 days); (2) patients with angina (6.8 ± 0.28 days) and without (6.6 ± 0.26 days); (3) patients with infarction (6.8 ± 0.26 days); and without (6.8 ± 0.50 days); (4) patients with varying patterns of arteriographic involvement; and (5) with varying smoking histories. Adhesiveness was normal in all. Aggregation was normal in 14. Neither adhesiveness nor aggregation correlated with platelet survival or defined the subgroups of CAD. Results suggest an abnormal short platelet survival frequently occurs in patients with CAD, but there is no discernible difference in platelet survival among the various clinical subgroups of CAD.

Key Words: Thrombosis • Atherosclerosis • Hyperlipoproteinemia • Myocardial infarction • Angina • Cigarette smoking

Submitted on May 2, 1973
Accepted on July 25, 1973

This article has been cited by other articles:

				C. J. Knight, M. Panesar, C. Wright, D. Clarke, P. S. Butowski, D. Patel, A. Patrineli, K. Fox, and A. H. Goodall Altered Platelet Function Detected by Flow Cytometry : Effects of Coronary Artery Disease and Age Arterioscler. Thromb. Vasc. Biol., October 1, 1997; 17(10): 2044 - 2053. [Abstract] [Full Text]

				J. T. Willerson and J. T. Willerson Peripheral Venous Platelet Aggregates in Patients With Unstable Angina Pectoris and Acute Myocardial Infarction Angiology, October 1, 1977; 28(10): 695 - 701. [Abstract] [PDF]