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(Circulation. 1974;49:338.)
© 1974 American Heart Association, Inc.

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Simultaneous Measurement of Total and Nutritional Coronary Blood Flow in Dogs

ADRIAN D. LEBLANC PH.D.¹; RICHARD C. RILEY PH.D.¹; RALPH G. ROBINSON M.D.¹

¹ From the Department of Diagnostic Radiology, University of Kansas Medical Center, Kansas City, Kansas.

Significant correlation has been shown between the severity of coronary disease and level of coronary blood flow as measured by the rubidium coincidence technique. Contrary to the commonly expressed view, however, the rubidium coincidence method does not evaluate nutritional flow, but estimates total coronary blood flow (CBF_T). An equation is derived that does evaluate nutritional flow (CBF_N), allowing simultaneous measurement of total and nutritional flow.

The extraction ratio of the total body (ER_TB) relative to the extraction ratio of the heart (ER_C) was measured in a total of 21 dogs by employing the relative uptake of labeled microspheres and diffusible ions, ⁸⁶Rb and ¹³¹Cs.

CBF_T, measured with a bolus injection of ⁸⁶Rb or ¹³¹Cs, was compared with total flow measured by the microsphere technique in dogs, with and without drug administration (norepinephrine, isoproterenol, nitroglycerin). These studies showed that while rubidium gives accurate mean values of total flow (4% mean difference, r = 0.92) individual estimates may be in error by as much as ± 42%. It was found, however, that isotopes of cesium are not suitable for measuring either total or nutritional coronary blood flow by the methods described in this paper.

Comparison of CBF_N with CBF_T showed that not only was CBF_N significantly less than CBF_T, but the percentage increase in CBF_N was significantly less than that of CBF_T after norepinephrine or isoproterenol administration.

Key Words: Rubidium-86 • Radioactive microspheres • Norepinephrine • Extraction ratios • Cesium-131 • Isoproterenol • Nitroglycerin

Submitted on May 15, 1973
Accepted on September 24, 1973