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(Circulation. 1952;5:12.)
© 1952 American Heart Association, Inc.

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A Study of the Digitalis-like Action of Thevetoidin in Man

IGNACIO CHAVEZ M.D.¹; RAFAEL MÉNDEZ M.D.¹; LEONARDO 0. CHAIT M.D.¹

¹ From the Instituto Nacional de Cardiología, México, D. F., México.

The effect of thevetoidin in heart failure has been studied. Thevetoidin has a prompt and partly transient digitails-like effect which is shown on the heart rate, the circulatory velocity and on the P-R and Q-T intervals of the electrocardiogram, and also a cumulative effect similar to that of strophanthin. Due to its intense vagal effect and its quick digitails-like action, paroxysmal auricular tachycardia was stopped in two patients out of three in from three to four minutes. Its therapeutic advantages and disadvantages are discussed.