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(Circulation. 1952;5:20.)
© 1952 American Heart Association, Inc.

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The Treatment of Hypertension with Hexamethonium

EDWARD D. FREIS M.D.¹; FRANK A. FINNERTY JR. M.D.¹; HAROLD W. SCHNAPER M.D.¹; ROBERT L. JOHNSON M.C., U. S. A. F.¹

¹ From The Cardiovascular Research Laboratory, Georgetown University Hospital and the Department of Medicine, Georgetown University School of Medicine, the Georgetown Medical Division, Gallinger Municipal Hospital, and the Veterans Administration Hospital, Washington, D. C.

Hexamethonium by subcutaneous injection in doses of 10 to 75 mg. of the ion every 8 or 12 hours produced significant reductions of arterial pressure and symptomatic improvement in a high percentage of patients with benign or malignant hypertension. Methods for preventing tolerance and undesirable side effects are presented, and the advantages as well as the limitations of hexamethonium therapy are discussed.

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