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(Circulation. 1952;5:58.)
© 1952 American Heart Association, Inc.

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The Distribution of Body Fluids in Congestive Heart Failure

IV. Exchanges in Patients, Refractory to Mercurial Diuretics, Treated with Sodium and Potassium

J. H. ELKINTON M.D.¹; R. D. SQUIRES M.D.¹; L. W. BLUEMLE JR. M.D.¹

¹ From the Chemical Section of the Department of Medicine, and the Hospital of the University of Pennsylvania, Philadelphia, Pa.

The clinical course was observed and balance studies were conducted in a series of patients with congestive heart failure who had hyponatremia and who had become refractory to mercurial diuretics. The data obtained during control periods and during treatment with hypertonic sodium solutions suggest that, in addition to sodium depletion, some disturbance is present in the mechanisms which regulate the water balance of the body. The administration of potassium did not appear to effect a diuresis.

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