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(Circulation. 1952;5:370.)
© 1952 American Heart Association, Inc.

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Comparison of the Circulatory Effects of Epinephrine and Norepinephrine

KHALIL G. WAKIM M.D.¹ HIRAM E. ESSEX PH.D.¹

¹ From the Section on Physiology, Mayo Clinic, and the Division of Experimental Medicine, Mayo Foundation, University of Minnesota, Rochester, Minn.

A comparison was made of the circulatory effects of l-epinephrine and l-norepinephrine when various doses were given either intravenously or intra-arterially into anesthetized animals. No significant difference was found between the effects of identical doses of the two drugs on the arterial blood pressure, heart rate and blood flow. The intensity and duration of effect of either drug varied roughly with the dose given.