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(Circulation. 1952;5:380.)
© 1952 American Heart Association, Inc.

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Pressor Substances in Arterial Hypertension

IV. Quantitative and Qualitative Studies of Pherentasin

DEAN F. DAVIES PH.D., M.D.¹; NORMAN S. OLSEN PH.D.¹; HENRY A. SCHROEDER M.D.¹

¹ From the Hypertension Division, Department of Internal Medicine, and the Oscar Johnson Institute,Washington University School of Medicine, St. Louis, Mo.

Pherentasin is the only pressor substance found in blood of hypertensive patients which is not found in normal blood. This study defines its unit and compares its concentration with diastolic blood pressure level, type of hypertension, and age of patients. Lack of correlation between blood pressure level and pherentasin content suggests considerable variation in the amount of depressor substances in these patients. Chemical studies of pherentasin and its partial, tentative formula are discussed. Demonstration of the existence of an additional pressor fraction from blood which is volatile in alkaline solution is described.