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(Circulation. 1952;5:397.)
© 1952 American Heart Association, Inc.

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Effect of Athyroid State on Vascular Reactivity and Arterial Pressure in Neurogenic and Renal Hypertensive Dogs

JAMES W. MCCUBBIN M.D.¹ IRVINE H. PAGE M.D.¹

¹ From the Research Division of the Cleveland Clinic Foundation, and the Frank E. Bunts Educational Institute, Cleveland, Ohio.

Since vascular responsiveness to adrenaline, noradrenaline, renin and angiotonin is reduced by suppression of thyroidal function in normotensive dogs, it was a possibility that in neurogenic and renal hypertensive animals suppression of thyroidal function might be associated with decrease in arterial pressure. This possibility was not confirmed, hypertension persisting unaltered in both groups of hypertensive animals over long periods of observation. Changes in vascular reactivity were slight in comparison with those associated with the athyroid state in normotensive dogs.