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(Circulation. 1952;5:401.)
© 1952 American Heart Association, Inc.

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The Relationship of Serum Lipoproteins to Atherosclerosis in the Cholesterol-Fed Alloxanized Rabbit

FRANK T. PIERCE JR. M.D.¹

¹ From the Donner Laboratory and the Radiation Laboratory, Division of Medical Physics, University of California, Berkeley, Calif.

The alloxanized rabbit fed cholesterol develops extreme hyperlipemia and hypercholesteremia and yet develops a lesser degree of atherosclerosis than does the normal animal fed cholesterol. The concentrations of the S_f 12-30 and S_f 20-30 classes of lipoproteins correlate well with atherosclerosis as finally observed in the alloxanized rabbit, whereas both free and total serum cholesterol correlate negatively with atherosclerosis. In the alloxan-diabetic rabbit, the serum cholesterol is principally carried in the S_f 80-100 and greater classes of lipoproteins, and a metabolic block in the conversion of these lipoproteins to those of S_f 40 and less can be demonstrated.

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