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(Circulation. 1952;5:524.)
© 1952 American Heart Association, Inc.

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Use of a Combination of Anion and Cation Exchange Resins in the Treatment of Edema and Ascites

B. L. MARTZ M.D.¹; K. G. KOHLSTAEDT M.D.¹; O. M. HELMER PH.D.¹

¹ From the Lilly Laboratory for Clinical Research, General Hospital, Indianapolis, Ind.

A mixture of a carboxylic acid type of cation exchange resin and a weakly basic anion exchange resin has been used successfully to control the edema of 42 patients with congestive heart failure and the ascites of 14 patients with cirrhosis of the liver. Approximately one-third of the cation exchanger was supplied in the potassium cycle.

Inclusion of the anion exchange resin resulted in a greater sodium uptake per gram of resin and apparently decreased the incidence of disturbances in acid-base balance in patients with impaired renal function who were treated with resins.