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Circulation. 1952;5:583-588

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(Circulation. 1952;5:583.)
© 1952 American Heart Association, Inc.

The Factors Influencing the Circulation Time

MORTON LEE PEARCE M.D.1; ALVIN E. LEWIS M.D.1; MELVIN R. KAPLAN M.D.1

1 From the Departments of Medicine and Pathology, University of California at Los Angeles, School of Medicine, and Los Angeles County Harbor Hospital, Los Angeles, Calif.

A mathematical analysis of the relationship of cardiac output and heart-lung blood volume to observed circulation time is presented. The theoretic conclusions are substantiated by an experiment in which it is shown that diluting the amount of indicator used prolongs the observed circulation time through the heart and lungs.






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