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(Circulation. 1952;5:824.)
© 1952 American Heart Association, Inc.

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The Effects of Increased Intracranial Pressure on the Pulmonary Circulation in Relation to Pulmonary Edema

WILLIAM HARRISON M.D.¹ AVERILL A. LIEBOW M.D.¹

¹ From the Department of Pathology, Yale University School of Medicine, New Haven, Conn., in contract with the Office of Naval Research, as Project N6ori-44, Task Order XI.

Sudden elevation of intracranial pressure raises not only the systemic but also the pulmonary intravascular pressures, on occasion, sufficiently to result in pulmonary edema. At least two mechanisms are concerned, that of bradycardia, and that of left ventricular failure. Evidence is presented that interruption of vagal inflow temporarily abolishes the first mechanism. These observations are considered in relation to the clinical problem of head injury.