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(Circulation. 1952;5:903.)
© 1952 American Heart Association, Inc.

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Nutritional Factors in Hemodynamics

II. Hypertension during Pteroylglutamic Acid Administration in Albino Rats

RICHARD E. LEE M.D., PH.D.¹; SACHIKO TANAKA B.A.¹; ELIZABETH A. HOLZE B.A.¹

¹ From the Department of Medicine, Cornell University Medical Center, the New York Hospital, New York, N. Y., and the Federal Security Agency, Public Health Service, National Heart Institute, National Institutes of Health, Bethesda, Md.

Albino rats treated with pteroylglutamic acid (PGA) developed a significant increase in blood pressure, as compared with litter mate controls of the same sex. The hypertension was associated with wedge-shaped fibroblastic renal cortical lesions. Factors possibly important etiologically in the elevation of blood pressure are discussed in relation to certain of the metabolic roles of pteroylglutamic acid.

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