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(Circulation. 1974;50:653.)
© 1974 American Heart Association, Inc.

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Correlation of Serum Concentrations with Heart Concentrations of Digoxin in Human Subjects

H. -G. GÜLLNER M.D.¹; E. B. STINSON M.D.¹; D. C. HARRISON M.D.¹; S. M. KALMAN M.D.¹

¹ From the Department of Pharmacology, Division of Cardiovascular Surgery, and Division of Cardiology, Stanford University, Stanford, California.

Biopsies of cardiac tissue were taken from patients undergoing surgery for coronary artery or valvular disease. All subjects were on maintenance doses of digoxin, which were stopped 48 hours before surgery. The ratios, heart:serum, for digoxin content were remarkably similar and the variance was small.

Key Words: Atrial biopsies • Digoxin in human heart • Tissue:serum ratios of digoxin

Submitted on January 15, 1974
Accepted on June 25, 1974