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(Circulation. 1974;50:665.)
© 1974 American Heart Association, Inc.

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The Effects of Propranolol on Induction of A-V Nodal Reentrant Paroxysmal Tachycardia

DELON WU M.D.¹; PABLO DENES M.D.¹; RAMESH DHINGRA M.D.¹; ASHFAQUE KHAN M.D.¹; KENNETH M. ROSEN M.D.¹

¹ From the University of Illinois College of Medicine, Chicago, Illinois, and West Side Veterans Administration Hospital, Chicago, Illinois.

Twelve patients with paroxysmal supraventricular tachycardia (PSVT) were studied before and after administration of 0.1 mg/kg i.v. propranolol. Echo zones for inducing atrioventricular (A-V) nodal reentry were determined using His bundle recording and the atrial extrastimulus technique. After propranolol the echo zone was abolished in two patients, decreased in one, unchanged in five, increased in two. In two patients echo zones appeared only after propranolol. Nine patients had episodes of sustained PSVT prior to propranolol. Following propranolol PSVT persisted in only five. In these five patients propranolol slowed the rate of PSVT.

The data were analyzed by plotting A₁-A₂ and H₁-H₂ interval curves. On the basis of these curves the patients were separated into those with "dual pathways" and those with "reflection." The effects of propranolol on both conduction patterns are discussed.

In summary, the actions of propranolol in PSVT patients were variable. Potentially beneficial effects included slowing of induced PSVT, loss of the ability to sustain PSVT, and decrease or total elimination of echo zones. Potentially deleterious effects included potentiation of the echo phenomenon with either increase or development of echo zones.

Key Words: Echo zones • Reflection • His bundle electrogram • Critical A-H • Atrial extrastimulus • Effective refractory period • Dual atrioventricular nodal pathways • Wenckebach period • Functional refractory period

Submitted on December 19, 1973
Accepted on May 17, 1974

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