This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by PROKOP, E. K. Articles by WAGNER, H. N. Search for Related Content PubMed PubMed Citation Articles by PROKOP, E. K. Articles by WAGNER, H. N., JR.

(Circulation. 1974;50:978.)
© 1974 American Heart Association, Inc.

---

Comparison of Regional Myocardial Perfusion Determined by Ionic Potassium-43 to That Determined by Microspheres

EDWARD K. PROKOP M.D.¹; H. WILLIAM STRAUSS M.D.¹; JOHN SHAW M.D.¹; BERTRAM PITT M.D.¹; HENRY N. WAGNER JR. M.D.¹

¹ From the Division of Nuclear Medicine, Department of Radiology, and the Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205.

The ability of ionic potassium-43 (⁴³K) to reflect alterations in regional myocardial perfusion was determined by comparing the distribution of this tracer to that of labeled microspheres and flowmeter measurements under several conditions of coronary blood flow. When flow was normal, the regional distribution of ionic ⁴³K and labeled microspheres were similar. In ischemia induced by partial occlusion and pacing, both ⁴³K and microspheres showed the same decrease in activity (0.7 of control). When a coronary artery was completely occluded, both tracers were decreased to 0.3 of control. In other experiments, resting coronary blood flow was decreased by 25%, 50% and 75% as determined by flowmeter measurements. When this was done, regional distribution of ionic ⁴³K and microspheres both decreased in parallel but to a lesser degree than flowmeter data suggesting a contribution from collateral vessels. The endocardial/epicardial activity in the ischemic region also decreased proportionally. However, under conditions of increased flow during myocardial reactive hyperemia, ⁴³K activity (1.02 of control) did not increase to the same degree as microsphere activity (1.5 of control).

Key Words: Radioisotope • Hyperemia • Infarction • Ischemia • Coronary blood flow

Submitted on April 5, 1974
Accepted on July 22, 1974

This article has been cited by other articles:

				P. A. Kaufmann and P. G. Camici Myocardial Blood Flow Measurement by PET: Technical Aspects and Clinical Applications J. Nucl. Med., January 1, 2005; 46(1): 75 - 88. [Full Text] [PDF]

				P. Chareonthaitawee, P. A Kaufmann, O. Rimoldi, and P. G Camici Heterogeneity of resting and hyperemic myocardial blood flow in healthy humans Cardiovasc Res, April 1, 2001; 50(1): 151 - 161. [Abstract] [Full Text] [PDF]