Circulation, Vol 51, 614-620, Copyright © 1975 by American Heart Association
RM Norris, RM Whitlock, C Barratt-Boyes and CW Small
A modified method for the measurement of total creatine phosphokinase
release from venous blood samples taken four-hourly after myocardial
infarction has been used in 43 patients admitted to a Coronary Care Unit.
The fractional decay rate (Kd) of enzyme activity has been measured by a
standardized method in each patient, and accuracy of the calculation of
total enzyme release has been improved by allowance for individual
variations in decay rate, and discarding of data from which decay rates
cannot be measured within confidence limits of less than plus or minus 15
per cent. Total enzyme release was greater in cases of transmural
infarction than in patients with subendocardial infarction, and showed a
good positive correlation with clinical indices of the extent of myocardial
damage. As noted by previous workers, this method allows for the
measurement of the rate as well as the extent of enzyme release, and so
should prove useful in the clinical evaluation of therapeutic agents which
might accelerate or retard the rate of myocardial necrosis in patients with
acute myocardial infarction.
ARTICLES
Clinical measurement of myocardial infarct size. Modification of a method for the estimation of total creatine phosphokinase release after myocardial infarction
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