This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Solis, R. T. Articles by DeBakey, M. E. Search for Related Content PubMed PubMed Citation Articles by Solis, R. T. Articles by DeBakey, M. E.

Circulation, Vol 52, 103-108, Copyright © 1975 by American Heart Association

ARTICLES

Cardiopulmonary bypass. Microembolization and platelet aggregation

RT Solis, PS Kennedy, AC Beall Jr, GP Noon and ME DeBakey

Particulate microemboli and in vitro platelet aggregation were studied in blood of patients during cardiac operations with an electronic particle size analyzer. A small gradient of microemboli developed on passage of blood through a bubble oxygenator but not through a membrane oxygenator. However, with both types of oxygenators, there was a sustained increase in the volume of microemboli in cardiotomy return blood which was much greater than in aterial blood. After cardiopulmonary bypass with both oxygenators, there was a comparable reduction in the volume of circulating platelets which exceeded that of the hemoglobin concentration, indicating platelet loss exceeded that that expected from hemodilution alone. However, the total volume and mean size of platelet aggregates induced in blood of patients after membrane oxygenation was significantly greater than similar measurements after bubble oxygenation. This study shows that membrane oxygenation reduces particulate microembolization and preserves platelet function in patients undergoing cardiac operations when compared to bubble oxygenation.

This article has been cited by other articles:

				R. A Rodriguez, K. A Williams, A. Babaev, F. Rubens, and H. J Nathan Effect of perfusionist technique on cerebral embolization during cardiopulmonary bypass Perfusion, January 1, 2005; 20(1): 3 - 10. [Abstract] [PDF]

				L H. Edmunds Jr The evolution of cardiopulmonary bypass: lessons to be learned Perfusion, July 1, 2002; 17(4): 243 - 251. [Abstract] [PDF]

				G. J Peek, A. Thompson, H. M Killer, and R. K Firmin Spallation performance of extracorporeal membrane oxygenation tubing Perfusion, September 1, 2000; 15(5): 457 - 466. [Abstract] [PDF]

				G. J Peek, K. Wong, C. Morrison, H. M Killer, and R. K Firmin Tubing failure during prolonged roller pump use: a laboratory study Perfusion, December 1, 1999; 14(6): 443 - 452. [Abstract] [PDF]

				J. A. Hyde, J. A Chinn, and T. R Graham Platelets and cardiopulmonary bypass Perfusion, December 1, 1998; 13(6): 389 - 407. [PDF]

				A. Weerasinghe and K. M. Taylor The platelet in cardiopulmonary bypass Ann. Thorac. Surg., December 1, 1998; 66(6): 2145 - 2152. [Abstract] [Full Text] [PDF]

				P. L. Smith The systemic inflammatory response to cardiopulmonary bypass and the brain Perfusion, May 1, 1996; 11(3): 196 - 199. [PDF]

				P. Hornick and A. George Blood contact activation: pathophysiological effects and therapeutic approaches Perfusion, January 1, 1996; 11(1): 3 - 19. [PDF]

				P. Hornick Carotid artery disease and myocardial revascularization Perfusion, January 1, 1994; 9(5): 309 - 317. [PDF]

				J. Desai and S. Ohri Review article : Gastrointestinal damage following cardiopulmonary bypass Perfusion, July 1, 1990; 5(3): 161 - 168. [PDF]

				B. Butler and M. Kurusz Review article : Gaseous microemboli: a review Perfusion, April 1, 1990; 5(2): 81 - 99. [PDF]

				M. Sellman, T. Ivert, P. Stensved, M. Hogberg, and B. Semb Doppler ultrasound estimation of microbubbles in the arterial line during extracorporeal circulation Perfusion, January 1, 1990; 5(1): 23 - 32. [Abstract] [PDF]

				D.T. Pearson and B. McArdle Haemocompatibility of membrane and bubble oxygenators Perfusion, January 1, 1989; 4(1): 9 - 24. [Abstract] [PDF]

				T. Spyt, D. Wheatley, I. Walker, J. Davidson, K. MacArthur, and W. Martin Placebo-controlled study of Iloprost (ZK 36374) in cardiopulmonary bypass surgery Perfusion, July 1, 1988; 3(3): 179 - 186. [Abstract] [PDF]

				K. Taylor Review article : Vasopressor release and multiple organ failure in cardiac surgery Perfusion, January 1, 1988; 3(1): 1 - 16. [PDF]

				K. Taylor Review article : Prostacyclin therapy during cardiopulmonary bypass is it beneficial? Perfusion, January 1, 1987; 2(1): 1 - 7. [PDF]

				P. Boonstra, F. Vermeulen, J. Leusink, E. de Nooy, A. van Zalk, J. Soons, and C. Wildevuur Platelet damage and haemolysis during bubble oxygenator perfusion with and without arterial line filter, compared to membrane oxygenator perfusion Perfusion, January 1, 1987; 2(1): 27 - 33. [Abstract] [PDF]

				M. Abela, B. McArdle, M. Qureshi, and D. Pearson Heparin-enhanced ADP-induced platelet aggregation in patients undergoing cardiopulmonary bypass surgery Perfusion, July 1, 1986; 1(3): 175 - 178. [Abstract] [PDF]

				D. T Pearson, B. McArdle, S. J Poslad, and A. Murray A clinical evaluation of the performance characteristics of one membrane and five bubble oxygenators: haemocompatibility studies Perfusion, January 1, 1986; 1(2): 81 - 98. [Abstract] [PDF]