Circulation, Vol 52, 49-57, Copyright © 1975 by American Heart Association
LH Opie, K Bruyneel and P Owen
The effects of infusions of glucose, insulin and potassium (GIK) on the
heart tissue metabolic changes found in adult baboons 60 min after coronary
artery ligation were studied. Biopsies taken from 11 baboons without
coronary artery ligation gave control values. A second group of 46 baboons
had coronary artery ligation. A third group of 17 baboons received an
infusion of KCl after coronary artery ligation. A fourth group of 26
baboons received infusion of GIK. Coronary artery ligation resulted in the
expected fall of ATP, creatine phosphate, glycogen, tissue (K+/Na+) ratio,
and tissue pH, and rise of inorganic phosphate, lactare, lactate/pyruvate
ratio and alpha-glycerophosphate in the infarction zones. Compared with
ligation, additional infusions of GIK approximately doubled the contents of
creatine phosphate and glycogen in the infarct zones, increased the content
of ATP in the central infarct zone, and decreased the content of inorganic
phosphate in the peripheral infarct zone. Other GIK effects were that the
tissue (K+/Na+) ratio rose in the peripheral infarct zone, and the content
of both glycogen and lactate rose in the peri-infarct and non-ischemic
zones; the pH of tissue homogenates did not decrease. KCl infusions had few
effects compared with the ligation group. GIK infusions exerted a
beneficial effect when compared with infusions of KCl in that tissue
creatine phosphate rose in the peripheral infarct and nonischemic zones;
the tissue K+/Na+ ratio rose in the peripheral infarct, peri- infarct, and
nonischemic zones; and the lactate/pyruvate ratio fell in the infarct zone.
It is proposed that GIK counteracted early tissue metabolic deterioration
in the infarcting baboon heart.
ARTICLES
Effects of glucose, insulin and potassium infusion on tissue metabolic changes within first hour of myocardial infarction in the baboon
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