Circulation, Vol 52, 848-853, Copyright © 1975 by American Heart Association
HL Falsetti, RJ Carroll and ML Marcus
Temporal variation in perfusion to small segments of the myocardium was
studied in 19 opened-chest dogs. In six control dogs, three or four
differently labeled 7-10 mu microspheres were injected simultaneously into
the left atrium to assess the variability in measured myocardial perfusion
due to the microsphere technique. In 13 other dogs, microspheres were
injected four times at 5 minute intervals while various hemodynamics
parameters (mean aortic pressure, peak systolic pressure, heart rate, left
ventricular end-diastolic pressure, and Vmax) were stable (less than 10%
variation in any one parameter). The left ventricles were divided into 96
segments, the mean weight+/- SD of each segment was 0.95+/-0.17 grams. The
flow to each segment was expressed as a percent of the mean flow of the
three or four measured flows to that segment, and the difference between
the largest and the smallest percent of each segment was taken as a measure
of the variability of flow to that segment. The average variability of
segmental flow (mean +/-SD) when the three to four differently labeled
microspheres were injected was 14.0+/-4.7; and the variability when
differently labeled microspheres injected sequentially was 31.0+/-10.8% (P
less than 0.001). Furthermore, in the sequentially injected animals the
magnitude of temporal variation was similar in various subdivisions of the
ventricle (layers, walls, apex to base). The mean and standard deviation of
the variability of flow to the endo, mid, and epicardial layers were
28.7+/-10.2, 30.0+/-11.3 and 34.5+/-12.4%, respectively. These changes may
reflect either spontaneous or local autoregulatory changes in precapillary
sphincters or arterioles.
ARTICLES
Temporal heterogeneity of myocardial blood flow in anesthetized dogs
This article has been cited by other articles:
 |
|
 |
|
  M. Kostelec, J. Covell, G. D. Buckberg, A. Sadeghi, J. I.E. Hoffman, and G. S. Kassab Myocardial protection in the failing heart: I. Effect of cardioplegia and the beating state under simulated left ventricular restoration J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 875 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Kassab, M. Kostelec, G. D. Buckberg, J. Covell, A. Sadeghi, and J. I.E. Hoffman Myocardial protection in the failing heart: II. Effect of pulsatile cardioplegic perfusion under simulated left ventricular restoration J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Mansaray, P.R Belcher, I Vergroesen, Z.M Wright, J.W Hynd, A.J Drake-Holland, and M.I.M Noble Downstream resistance effects of intracoronary thrombosis in the stenosed canine coronary artery Cardiovasc Res, April 1, 1999; 42(1): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Z. Linka, D. M. Skyba, R. J. Price, K. Wei, T. C. Skalak, and S. Kaul Spontaneous redistribution after reperfusion: A unique property of AIP 201, an ultrasound contrast agent J. Am. Coll. Cardiol., November 15, 1998; 32(6): 1765 - 1772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Kasprzak, W. B. Vletter, J. R.T.C. Roelandt, J. R. van Meegen, R. Johnson, and F. J. Ten Cate Visualization and quantification of myocardial mass at risk using three-dimensional contrast echocardiography Cardiovasc Res, November 1, 1998; 40(2): 314 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ghaleh, Y.-T. Shen, and S. F. Vatner Spatial Heterogeneity of Myocardial Blood Flow Presages Salvage Versus Necrosis With Coronary Artery Reperfusion in Conscious Baboons Circulation, November 1, 1996; 94(9): 2210 - 2215. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Hasdai, L. Fuchs, D. Ohad, and A. Battler The Applicability of Color-Labeled Microspheres in a Rabbit Model of Ischemia-Reperfusion Angiology, June 1, 1994; 45(6): 461 - 467. [Abstract] [PDF]
|
|