This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Neill, W. A. Articles by Hattenhauer, M. Search for Related Content PubMed PubMed Citation Articles by Neill, W. A. Articles by Hattenhauer, M.

Circulation, Vol 52, 854-858, Copyright © 1975 by American Heart Association

ARTICLES

Impairment of myocardial O2 supply due to hyperventilation

WA Neill and M Hattenhauer

Thirteen patients with ischemic coronary heart disease purposely hyperventilated for seven minutes in order to induce hypocapnic alkalosis. One patient experienced chest pain, and one exhibited chemical signs of myocardial hypoxia. Heart rate, blood pressure and myocardial O2 consumption did not change significantly. Coronary blood flow decreased and coronary (a-v)O2 difference widened. Since the alkalosis increased the blood O2 affinity, the fall in PO2 in coronary venous blood was proportionately even greater than the fall in O2 concentration. Thus, hypocapnic alkalosis due to hyperventilation interferes with myocardial O2 supply by 1) coronary vasoconstriction and 2) increased O2 affinity of blood.

This article has been cited by other articles:

				J. J. Rutherford, T. H. Clutton-Brock, and M. J. Parkes Hypocapnia reduces the T wave of the electrocardiogram in normal human subjects Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R148 - R155. [Abstract] [Full Text] [PDF]

				D. Rennie Will Mountains Trekkers Have Heart Attacks? JAMA, February 17, 1989; 261(7): 1045 - 1046. [Abstract] [PDF]

				F. A. Gaffney, B. J. Fenton, L. D. Lane, and C. R. Lake Hemodynamic, Ventilatory, and Biochemical Responses of Panic Patients and Normal Controls With Sodium Lactate Infusion and Spontaneous Panic Attacks Arch Gen Psychiatry, January 1, 1988; 45(1): 53 - 60. [Abstract] [PDF]

				J. C. Missri and S. Alexander Hyperventilation Syndrome: A Brief Review JAMA, November 3, 1978; 240(19): 2093 - 2096. [Abstract] [PDF]

				T. F. Waites Hyperventilation--Chronic and Acute Arch Intern Med, November 1, 1978; 138(11): 1700 - 1701. [Abstract] [PDF]