This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Horowitz, L. N. Articles by Moore, E. N. Search for Related Content PubMed PubMed Citation Articles by Horowitz, L. N. Articles by Moore, E. N. Pubmed/NCBI databases Medline Plus Health Information Arrhythmia Heart Attack

Circulation, Vol 53, 56-63, Copyright © 1976 by American Heart Association

ARTICLES

Subendocardial origin of ventricular arrhythmias in 24-hour-old experimental myocardial infarction

LN Horowitz, JF Spear and EN Moore

In 12 anesthetized open-chest dogs, ventricular epicardial activation maps were constructed and electrograms were recorded from the bundle of His, left bundle branch, and subendocardial Purkinje fibers 24 hours following Harris 2-stage ligation of the left anterior descending coronary artery. All animals developed ectopic ventricular depolarizations and/or ventricular tachycardia. The earliest area of epicardial activation was located along the border of the infarct in the left ventricle in all animals. Bipolar recording from various levels of the conduction system and ventricular myocardium revealed that the earliest recorded electrical activity originated in subendocardial Purkinje fibers which had survived the acute myocardial infarction. The origin of these arrhythmias was further studied by pacing through the electrode which had recorded the early Purkinje activity and comparing the surface ECG and activation sequence with that of the spontaneous rhythm. These data tend to support the hypothesis that ventricular arrhythmias occurring 24-72 hours following acute myocardial infarction have their origin in the subendocardial Purkinje network which has survived the infarction.

This article has been cited by other articles:

				R. Coronel, F. J. G. Wilms-Schopman, and J. R. deGroot Origin of ischemia-induced phase 1b ventricular arrhythmias in pig hearts J. Am. Coll. Cardiol., January 2, 2002; 39(1): 166 - 176. [Abstract] [Full Text] [PDF]

				D. O. Arnar, J. R. Bullinga, and J. B. Martins Role of the Purkinje System in Spontaneous Ventricular Tachycardia During Acute Ischemia in a Canine Model Circulation, October 7, 1997; 96(7): 2421 - 2429. [Abstract] [Full Text]

				S. Ranger and S. Nattel Determinants and Mechanisms of Flecainide-Induced Promotion of Ventricular Tachycardia in Anesthetized Dogs Circulation, September 1, 1995; 92(5): 1300 - 1311. [Abstract] [Full Text]

				L. N. HOROWITZ, A. H. HARKEN, M. E. JOSEPHSON, and J. A. KASTOR Surgical Treatment of Ventricular Arrhythmias in Coronary Artery Disease Ann Intern Med, July 1, 1981; 95(1): 88 - 97. [Abstract] [PDF]

				J. Lewis and B. Kottke Endothelial damage and thrombocyte adhesion in pigeon atherosclerosis Science, May 27, 1977; 196(4293): 1007 - 1009. [Abstract] [PDF]