Circulation, Vol 53, 302-314, Copyright © 1976 by American Heart Association
P Theroux, J Ross Jr, D Franklin, WS Kemper and S Sasyama
Regional myocardial function following occlusions of the circumflex
coronary artery was studied in unanesthetized dogs using minature
ultrasonic crystal pairs implanted subendocardially within the left
ventricle for measurement of control, marginal, and ischemic lengths. As
early as five beats after coronary occlusion, reduced function was apparent
in ischemic zones, and an increase in heart rate occurred (78 to 115
beats/min) at an average of 25 sec. In the control zones, shortening
initially increased from a constant end-diastolic length, but later
end-diastolic length also increased by 7.5%. Shortening in the marginal
zones was reduced by 50% at 90 sec as holosystolic expansion developed in
the ischemic zones. On reperfusion, systolic function returned to normal
within a few minutes while protodiastolic abnormalities persisted for up to
45 min. With coronary occlusions longer than two minutes most dogs
exhibited arousal and further tachycardia; this reaction was prevented by
morphine. During two minute occlusions morphine also decreased the heart
rate increase by 37%, and marginal segment shortening was improved by 40%.
Prior administration of propranolol also decreased heart rate during
coronary occlusion and produced similar improvement in marginal segment
function; however, in contrast to morphine, there was depression of
contraction in the control segments. Nitroglycerin given during coronary
occlusion caused decreases in end-diastolic length of all segments and
increased shortening in the marginal segment by 28%. Lidocaine administered
during coronary occlusion produced a mild depression of myocardial function
in all regions of the heart.
ARTICLES
Regional Myocardial function in the conscious dog during acute coronary occlusion and responses to morphine, propranolol, nitroglycerin, and lidocaine
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