Circulation, Vol 53, 464-473, Copyright © 1976 by American Heart Association
W Markiewicz, J Stoner, E London, SA Hunt and RL Popp
Clinical, electrocardiographic, phonocardiographic, and echocardiographic
examinations were performed in 100 presumably healthy young females.
Treadmill testing and ambulatory electrocardiographic monitoring were
performed in a selected group of these subjects. Phonocardiograms, recorded
with the subjects supine at rest, after inhalation of amyl nitrite, and in
the upright position, revealed a 17% incidence of nonejection clicks and/or
late or mid- to late systolic murmurs (PHONO-MSCLSM). Echocardiographic
studies were performed in the second, third, fourth, and fifth intercostal
space with emphasis on the importance of transducer angulation on the
chest. Studies obtained with the transducer perpendicular to the chest in
the sagittal plane, or pointing cephalad at a time when both mitral
leaflets and left atrium are recorded, are optimal to study the mitral
valve systolic motion. With the transducer in this position, 21 subjects
were found to have pansystolic or late systolic prolapse, as previously
defined on the echocardiogram. The presence of these echocardiographic
findings was statistically related to the presence of PHONO-MSCLSM. Other
echocardiographic patterns were identified and their relation to PHONO-
MSCLSM and transducer position is discussed. Ten subjects with both
echocardiographic evidence of mitral valve prolapse and PHONO-MSCLSM were
identified (group EP), while 18 other subjects had either echocardiographic
or phonocardiographic findings suggestive of mitral valve abnormality
(group EorP). Seventy-two subjects had no abnormality (group noEP). The
incidence of various clinical, electrocardiographic, and echocardiographic
findings in these three groups was determined. Some findings said to be
common in patients with proven mitral valve prolapse were seen more
frequently in group EP subjects. Echocardiographic and phonocardiographic
findings suggesting mitral valve abnormalities were found more commonly
than expected in a population of presumably healthy young females.
ARTICLES
Mitral valve prolapse in one hundred presumably healthy young females
This article has been cited by other articles:
 |
|
 |
|
  R. Roberts Another Chromosomal Locus for Mitral Valve Prolapse: Close but No Cigar Circulation, September 27, 2005; 112(13): 1924 - 1926. [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Nasuti, P. J. Zhang, M. D. Feldman, T. Pasha, J. S. Khurana, J. H. Gorman III, R. C. Gorman, J. Narula, and N. Narula Fibrillin and other matrix proteins in mitral valve prolapse syndrome Ann. Thorac. Surg., February 1, 2004; 77(2): 532 - 536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Irvine, X K Li, D J Sahn, and A Kenny Assessment of mitral regurgitation Heart, November 1, 2002; 88(90004): iv11 - 19. [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Freed, E. J. Benjamin, D. Levy, M. G. Larson, J. C. Evans, D. L. Fuller, B. Lehman, and R. A. Levine Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study J. Am. Coll. Cardiol., October 2, 2002; 40(7): 1298 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Avierinos, B. J. Gersh, L. J. Melton III, K. R. Bailey, C. Shub, R. A. Nishimura, A. J. Tajik, and M. Enriquez-Sarano Natural History of Asymptomatic Mitral Valve Prolapse in the Community Circulation, September 10, 2002; 106(11): 1355 - 1361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Freed, D. Levy, R. A. Levine, M. G. Larson, J. C. Evans, D. L. Fuller, B. Lehman, and E. J. Benjamin Prevalence and Clinical Outcome of Mitral-Valve Prolapse N. Engl. J. Med., July 1, 1999; 341(1): 1 - 7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. H. C. Khoo, J. Parma, C. Rajasoorya, S. C. Ho, and G. Vassart A Germline Mutation of the Thyrotropin Receptor Gene Associated with Thyrotoxicosis and Mitral Valve Prolapse in a Chinese Family J. Clin. Endocrinol. Metab., April 1, 1999; 84(4): 1459 - 1462. [Abstract] [Full Text]
|
|
|
|
 |
|
 E. Etchells, C. Bell, and K. Robb Does This Patient Have an Abnormal Systolic Murmur? JAMA, February 19, 1997; 277(7): 564 - 571. [Abstract] [PDF]
|
|
|
|
|
|
C. J. Lavie, B. K. Khandheria, J. B. Seward, A. J. Tajik, C. L. Taylor, and D. J. Ballard Factors Associated With the Recommendation for Endocarditis Prophylaxis in Mitral Valve Prolapse JAMA, December 15, 1989; 262(23): 3308 - 3312. [Abstract] [PDF]
|
|
|
|
 |
|
 R. B. Devereux, R. Kramer-Fox, and P. Kligfield Mitral Valve Prolapse: Causes, Clinical Manifestations, and Management Ann Intern Med, August 15, 1989; 111(4): 305 - 317. [Abstract] [PDF]
|
|
|
|
 |
|
 T. O. Cheng and J. B. Barlow Mitral Leaflet Billowing and Prolapse: Its Prevalence Around the World Angiology, February 1, 1989; 40(2): 77 - 87. [Abstract] [PDF]
|
|
|
|
|
|
F. H. Zimmerman and A. H. Mogtader Ruptured Chordae Tendineae and Acute Pulmonary Edema Induced by Exercise: Occurrence in a Young Man With Mitral Valve Prolapse JAMA, August 14, 1987; 258(6): 812 - 813. [Abstract] [PDF]
|
|
|
|
 |
|
 G. L. Johnson, L. L. Humphries, P. B. Shirley, A. Mazzoleni, and J. A. Noonan Mitral Valve Prolapse in Patients With Anorexia Nervosa and Bulimia Arch Intern Med, August 1, 1986; 146(8): 1525 - 1529. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Retchin, R. H. Fletcher, J. Earp, N. Lamson, and R. A. Waugh Mitral Valve Prolapse: Disease or Illness? Arch Intern Med, June 1, 1986; 146(6): 1081 - 1084. [Abstract] [PDF]
|
|
|
|
|
|
L. M. Baddour, T. N. Phillips, and A. L. Bisno Coagulase-Negative Staphylococcal Endocarditis: Occurrence in Patients With Mitral Valve Prolapse Arch Intern Med, January 1, 1986; 146(1): 119 - 121. [Abstract] [PDF]
|
|
|
|
|
|
M. R. Griffin, W. R. Wilson, W. D. Edwards, W. M. O'Fallon, and L. T. Kurland Infective Endocarditis: Olmsted County, Minnesota, 1950 Through 1981 JAMA, September 6, 1985; 254(9): 1199 - 1202. [Abstract] [PDF]
|
|
|
|
|
|
S. M. Lippman, L. E. Ginzton, T. Thigpen, K. R. Tanaka, and M. M. Laks Mitral Valve Prolapse in Sickle Cell Disease: Presumptive Evidence for a Linked Connective Tissue Disorder Arch Intern Med, March 1, 1985; 145(3): 435 - 438. [Abstract] [PDF]
|
|
|
|
|
|
R. B. DEVEREUX, W. T. BROWN, R. KRAMER-FOX, and I. SACHS Inheritance of Mitral Valve Prolapse: Effect of Age and Sex on Gene Expression Ann Intern Med, December 1, 1982; 97(6): 826 - 832. [Abstract] [PDF]
|
|
|
|
|
|
R. E. Schatz and P. A. N. Chandraratna Mitral Valve Prolapse: Association With Bizarre Behavior, a Confusional State, and Aphasia Arch Intern Med, June 1, 1982; 142(6): 1215 - 1216. [Abstract] [PDF]
|
|
|
|
 |
|
 D. G. McNamara Idiopathic Benign Mitral Leaflet Prolapse: The Pediatrician's View Arch Pediatr Adolesc Med, February 1, 1982; 136(2): 152 - 156. [Abstract] [PDF]
|
|
|
|
|
|
K. B. Desser, S. I. Bokhari, A. Benchimol, and D. Romney All in the Family: Matrimonial Mitral Valve Clicks Angiology, May 1, 1981; 32(5): 355 - 360. [Abstract] [PDF]
|
|
|
|
|
|
M. D. Cheitlin and R. C. Byrd The Click-Murmur Syndrome: A Clinical Problem in Diagnosis and Treatment JAMA, April 3, 1981; 245(13): 1357 - 1361. [Abstract] [PDF]
|
|
|
|
|
|
C. M. Nolan, J. J. Kane, and W. A. Grunow Infective Endocarditis and Mitral Prolapse A Comparison With Other Types of Endocarditis Arch Intern Med, March 1, 1981; 141(4): 447 - 450. [Abstract] [PDF]
|
|
|
|
|
|
R. L. POPP, D. S. RUBENSON, C. R. TUCKER, and J. W. FRENCH Echocardiography: M-Mode and Two-Dimensional Methods Ann Intern Med, December 1, 1980; 93(6): 844 - 856. [Abstract] [PDF]
|
|
|
|
 |
|
 R. G. Kathol, R. Noyes Jr, D. J. Slymen, R. R. Crowe, J. Clancy, and R. E. Kerber Propranolol in Chronic Anxiety Disorders: A Controlled Study Arch Gen Psychiatry, December 1, 1980; 37(12): 1361 - 1365. [Abstract] [PDF]
|
|
|
|
|
|
R. B. Whiting Ventricular Premature Contractions Which Should Be Treated? Arch Intern Med, November 1, 1980; 140(11): 1423 - 1426. [Abstract] [PDF]
|
|
|
|
|
|
N. G. Kounis Mitral Valve Prolapse: Whiplike Motion of the Posterior Mitral Leaflet Detected by Two-Dimensional Echocardiography Angiology, March 1, 1980; 31(3): 198 - 209. [Abstract] [PDF]
|
|
|
|
|
|
R. R. Crowe, D. L. Pauls, D. J. Slymen, and R. Noyes A Family Study of Anxiety Neurosis: Morbidity Risk in Families of Patients With and Without Mitral Valve Prolapse Arch Gen Psychiatry, January 1, 1980; 37(1): 77 - 79. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Isner, R. J. Hawley, A. M. Weintraub, and W. K. Engel Cardiac Findings in Charcot-Marie-Tooth Disease: A Prospective Study of 68 Patients Arch Intern Med, October 1, 1979; 139(10): 1161 - 1165. [Abstract] [PDF]
|
|
|
|
|
|
R. R. Crowe, D. L. Pauls, A. Venkatesh, C. Van Valkenburg, R. Noyes Jr, J. B. Martins, and R. E. Kerber Exercise and Anxiety Neurosis: Comparison of Patients With and Without Mitral Valve Prolapse Arch Gen Psychiatry, June 1, 1979; 36(6): 652 - 653. [Abstract] [PDF]
|
|
|
|
|
|
R. Saffro and J. V. Talano Transient Ischemic Attack Associated With Mitral Systolic Clicks Arch Intern Med, June 1, 1979; 139(6): 693 - 694. [Abstract] [PDF]
|
|
|
|
|
|
A. N. DEMARIA The Syndrome of Mitral Valve Prolapse: Problems and Perspectives Ann Intern Med, October 1, 1976; 85(4): 525 - 526. [Abstract] [PDF]
|
|