Circulation, Vol 53, 792-796, Copyright © 1976 by American Heart Association
MM Bodenheimer, VS Banka, GA Hermann, RG Trout, H Pasdar and RH Helfant
Histopathologic-electrographic studies of ventriculography depicted
nitroglycerin responsive and unresponsive asynergic areas were performed in
25 patients. Of 29 areas, 12 improved with nitroglycerin, showing less than
10% muscle loss. Seventeen unimproved zones demonstrated significant
fibrosis. Epicardial electrograms showed R waves in eight of nine improved
zones. Of 11 unimproved zones, eight had Q waves.
Histopathologic-electrographic data from five responders showed less than
10% muscle loss, of whom four had epicardial R waves. Six unresponsive
areas had significant fibrosis, with a QS over four. Thus, nitroglycerin
responsive asynergic areas are generally comprised of histologically intact
myocardium and are associated with epicardial R waves.
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