Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation. 1976;53:985-988

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mroczek, W. J.
Right arrow Articles by Finnerty, F. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mroczek, W. J.
Right arrow Articles by Finnerty, F. A., Jr

Circulation, Vol 53, 985-988, Copyright © 1976 by American Heart Association

ARTICLES

Vasodilator administration in the presence of beta-adrenergic blockade

WJ Mroczek, WR Lee, ME Davidov and FA Finnerty Jr

To explore the possibility that the presence of propranolol-induced beta-adrenergic blockade might have an adverse effect upon homeostatic circulatory reflexes activated by the administration of a potent vasodilator agent, arterial blood pressure and pulse rate response to rapid intravenous diazoxide injection was monitored before and after pretreatment with propranolol in ten hypertensive patients. It appeared that beta-adrenergic blockade had no clinically significant effect on the magnitude of hypotension or the degree of heart rate acceleration induced by the administration of the potent vasodilator diazoxide. This reflex vasodilator-induced cardio-acceleration after propranolol adminstration could be the result of incomplete blockade of endogenously released neurotransmitter, inhibition of the parasympathetic nervous system, or a direct pharmacologic action of diazoxide. Diazoxide administration to hypertensive patients in the presence of beta-adrenergic blockade was not associated with any clinically significant hemodynamic consequences.


This article has been cited by other articles:


Home page
 CLIN PEDIATRHome page
W. W. McCrory, E. C. Kohaut, J. E. Lewy, E. Lieberman, and L. B. Travis
Safety of Intravenous Diazoxide in Children with Severe Hypertension
Clinical Pediatrics, November 1, 1979; 18(11): 661 - 671.
[Abstract] [PDF]


Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 1976 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.