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Circulation. 1976;54:14-20

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Circulation, Vol 54, 14-20, Copyright © 1976 by American Heart Association

ARTICLES

Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium

GA Klassen, F Sestier, A L'Abbate, RR Mildenberger and DT Zborowska-Sluis

Intravenous perhexiline maleate in a canine preparation with fixed coronary flow increases coronary diastolic pressure. It also redistributes coronary flow so as to preserve endocardial flow. Myocardial oxygen consumption was reduced and lactate uptake enhanced by the drug. It had no effect upon the threshold for ischemic-induced left ventricular failure.




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