Circulation, Vol 54, 14-20, Copyright © 1976 by American Heart Association
GA Klassen, F Sestier, A L'Abbate, RR Mildenberger and DT Zborowska-Sluis
Intravenous perhexiline maleate in a canine preparation with fixed coronary
flow increases coronary diastolic pressure. It also redistributes coronary
flow so as to preserve endocardial flow. Myocardial oxygen consumption was
reduced and lactate uptake enhanced by the drug. It had no effect upon the
threshold for ischemic-induced left ventricular failure.
ARTICLES
Effects of perhexiline maleate on coronary flow distribution in the ischemic canine myocardium
|
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 1976 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |