Circulation, Vol 54, 365-370, Copyright © 1976 by American Heart Association
JD Folts, EB Crowell Jr and GG Rowe
In 35 open chest anesthetized dogs coronary and aortic blood flow were
measured with electromagnetic flowmeters while aortic and distal coronary
blood pressure and an epicardial ECG were recorded. A fixed amount of
stenosis (60-80%) was produced in the coronary artery by an externally
applied plastic cylinder. In 24 of the 35 dogs the coronary blood flow
showed cyclical reductions to near zero, with a sudden spontaneous return
to near control levels. During reduced flow the epicardial ECG showed
ST-segment depression suggestive of ischemia, and ventricular premature
beats were often noted. Six animals died acutely during episodes of reduced
flow. After 35 mg/kg of aspirin were given intravenously the cyclical
reductions in coronary blood flow were abolished and the in vitro platelet
aggregations were reduced from a control of 62.1 +/- 15 units (Born
technique) to an average of 23.7 +/- 12 units. Histologic sections of the
narrowed coronary artery obtained when coronary flow was reduced show an
amorphous mass in the lumen which was thought to be a platelet aggregate.
Perhaps a similar process of platelet aggregation occurs in the stenosed
coronary arteries in man, producing acute coronary obstruction, ischemia,
and sudden death.
ARTICLES
Platelet aggregation in partially obstructed vessels and its elimination with aspirin
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