Circulation, Vol 55, 329-337, Copyright © 1977 by American Heart Association
BG Brown, E Bolson, M Frimer and HT Dodge
More accurate characterization of coronary artery lesions is needed for
evaluation of short and long-term interventions in coronary disease. A
method of segmental artery analysis has been developed to maximize the
information obtained from coronary arteriograms. Coronary lesions are
traced from two projected, perpendicular, 35 mm cineangiographic views and
transmetted, in digital form, to a PDP 11/45 computer. Magnification and
distortion of the image are compensated for in order to determine the
actual vessel profiles, using the catheter and its location as a scaling
device. The two views are matched; a spatial representation of the vessel
centerline is constructed mathematically; and orthogonal vessel diameters
are computed at increments along this centerline. Assuming an elliptical
lumen, the absolute and percentage reduction in diameter and
cross-sectional area in the stenosis are computed. More complex functions
(integrated atheroma mass, Poiseuille resistance, and orifice resistance)
are then calculated. The accuracy and variability of the different steps
involved in lesion analysis have been determined. Dimensional accuracies of
+/- 150 microns (SD) are feasible. Examples are given of patients with
Prinzmetal's angina and with progressive coronary disease.
ARTICLES
Quantitative coronary arteriography: estimation of dimensions, hemodynamic resistance, and atheroma mass of coronary artery lesions using the arteriogram and digital computation
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