Circulation, Vol 55, 394-400, Copyright © 1977 by American Heart Association
PE Klotman, CE Grim, MH Weinberger and WE Judson
Pulmonary hypertension has been described as a possible complication of the
antihypertensive vasodilator, minoxidil. A prospective study was undertaken
in seven severely hypertensive patients refractory to multiple drug
therapy. Treatment was initiated with fixed doses of hydrochlorothiazide
(100 mg/day) and propranolol (160 mg/day) for a control period. Mean
systemic arterial pressure, cardiac output, and pulmonary artery pressure
were then compared before and after the addition of acute (5 day) and
chronic (2 month) therapy with minoxidil. Mean arterial blood pressure
decreased from a control value of 135 mm Hg to a value of 104 mm Hg acutely
and 108 mm Hg chronically. Significant increases in mean cardiac output
occurred with minoxidil therapy (from 4.2 L/min control to 5.4 L/min
acutely and 5.1 L/min chronically) despite concomitant propranolol
treatment. Mean pulmonary artery pressure did not increase either acutely
or chronically. The data suggest that in patients with normal pulmonary
hemodynamics prior to treatment, pulmonary hypertension does not develop
during two months of minoxidil therapy.
ARTICLES
The effects of minoxidil on pulmonary and systemic hemodynamics in hypertensive man
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