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Circulation, Vol 55, 537-541, Copyright © 1977 by American Heart Association

ARTICLES

The effect of jejunoileal bypass on the pharmacokinetics of digoxin in man

FI Marcus, EJ Quinn, H Horton, S Jacobs, S Pippin, M Stafford and C Zukoski

Seven subjects who underwent jejunoileal bypass surgery for massive obesity participated in a study to examine the relative bioavailability of digoxin before and one to two months after surgery. They were given a loading dose of 1 mg digoxin in divided oral doses followed by oral maintenance doses of 0.5 mg daily. There were no significant differences in the area under the serum concentration time curve, steady state serum levels or 24 hour steady state excretion of digoxin before and after surgery. We conclude that the bioavailability of digoxin from the Lanoxin tablets employed is not impaired in these patients, although urinary d-xylose and 24 hour fecal fat excretion indicated moderate to severe malabsorption after surgery.