This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baxley, W. A. Articles by Pugh, D. Search for Related Content PubMed PubMed Citation Articles by Baxley, W. A. Articles by Pugh, D.

Circulation, Vol 55, 564-568, Copyright © 1977 by American Heart Association

ARTICLES

Left ventricular mechanical efficiency in man with heart disease

WA Baxley, HT Dodge, CE Rackley, H Sandler and D Pugh

Thirty-eight adults with valvular and/or myocardial disease had heart catheterization with coronary blood flow and myocardial O2 consumption (MVO2) per 100 g measured by the nitrous oxide washout technique. Quantitative biplane angiocardiography was performed to assess left ventricular volume, mass, ejection fraction and work. Left ventricular efficiency was calculated from work, MVO2/100 g and mass. Efficiency ranged from 4 to 40% and was normal in some patients with severe ventricular pressure-volume work overloads. Total left ventricular MVO2 ranged up to 461 ml/min. Neither total MVO2 nor MVO2/100 g was significantly related to ventricular work, ejection fraction, or tension-time index. These data suggest 1) a relationship between left ventricular efficiency and myocardial function in chronic valvular or myocardial disease, 2) that efficiency may be normal in hypertrophied ventricles, and 3) that chronic increases in resting ventricular metabolic requirements are met by hypertrophy rather than by increased MVO2/100 g.

This article has been cited by other articles:

				F. M. Bengel, P. Ueberfuhr, N. Schiepel, S. G. Nekolla, B. Reichart, and M. Schwaiger Myocardial Efficiency and Sympathetic Reinnervation After Orthotopic Heart Transplantation : A Noninvasive Study With Positron Emission Tomography Circulation, April 10, 2001; 103(14): 1881 - 1886. [Abstract] [Full Text] [PDF]

				S. Fazio, D. Sabatini, B. Capaldo, C. Vigorito, A. Giordano, R. Guida, F. Pardo, B. Biondi, and L. Sacca A Preliminary Study of Growth Hormone in the Treatment of Dilated Cardiomyopathy N. Engl. J. Med., March 28, 1996; 334(13): 809 - 814. [Abstract] [Full Text] [PDF]