Circulation, Vol 55, 892-895, Copyright © 1977 by American Heart Association
DS Sheps, JC Ernst, FR Briese, LV Lopez, CA Conde, A Castellanos and RJ Myerburg
Two exercise tests were performed with an intervening rest period of 45
minutes in a group of 13 subjects with previously identified exercise-
induced ventricular arrhythmias and no resting arrhythmias. Both normal
subjects and patients with heart disease were included in the group. The
level of stresss was equal in both tests as judged by similar rate-
pressure products at peak exercise. There was a significant decrease (P
less than 0.05) in the number of VPCs induced by exercise during and after
the second test. When the number of VPCs on test I and test II in the same
patients were compared, a regression line fitted the data well (r = 0.92).
Analysis of the recovery periods revealed significant (P less than 0.01)
decreases in systolic blood pressure at one and three minutes post
exercise, comparing the second to the first test. The underlying mechanism
may be decreased myocardial oxygen demand during the second test as the
lowered rate-pressure products during recovery (P less than 0.01) reflect.
The results of this study indicate that tests of effectiveness of an
antiarrhythmic drug should not be based solely on a decrease in the amount
of severity of ventricular irritability between two successive exercise
tests, one immediately before and the other following administration of the
drug.
ARTICLES
Decreased frequency of exercise-induced ventricular ectopic activity in the second of two consecutive treadmill tests
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