This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Corone, P. Articles by Gaudeul, P. Search for Related Content PubMed PubMed Citation Articles by Corone, P. Articles by Gaudeul, P.

Circulation, Vol 55, 908-915, Copyright © 1977 by American Heart Association

ARTICLES

Natural history of ventricular septal defect. A study involving 790 cases

P Corone, F Doyon, S Gaudeau, F Guerin, P Vernant, H Ducam, C Rumeau-Rouquette and P Gaudeul

The development of 790 untreated patients affected by ventricular septal defect (VSD) has been the object of a 25-year study. Of these patients, 72% had had at least one catheterization; 13% had several. The mean observation interval is six years, and the average age at the latest data is 19.5 years. This study covers 4717 patient-years. For the entire population, the incidence rate or aortic regurgitation is 6.3% (4.3 for 1000 patient-years) and that of bacterial endocarditis is 3.7% (2.4 for 1000 patient-years). Twenty-five patients died, 15 of them between the ages of one and 39. Of the 499 cases with several clinical examinations, 71% remained stable. In 21%, changes suggesting some level of closure developed; in 7%, infundibular stenosis began to evolve and in 1% pulmonary vascular disease began to appear or became accentuated. These different rates are studied and discussed in relation to patients' age, VSD type, and various follow-up characteristics.

This article has been cited by other articles:

				M K. Demirag, H. T. Keceligil, and F. Kolbakir Primary Surgical Repair of Ventricular Septal Defect Asian Cardiovasc Thorac Ann, September 1, 2003; 11(3): 213 - 216. [Abstract] [Full Text]

				H. M. Gabriel, M. Heger, P. Innerhofer, M. Zehetgruber, G. Mundigler, M. Wimmer, G. Maurer, and H. Baumgartner Long-term outcome of patients with ventricular septal defect considered not to require surgical closure during childhood J. Am. Coll. Cardiol., March 20, 2002; 39(6): 1066 - 1071. [Abstract] [Full Text] [PDF]

				A Nygren, J Sunnegårdh, and H Berggren Preoperative evaluation and surgery in isolated ventricular septal defects: a 21 year perspective Heart, February 1, 2000; 83(2): 198 - 204. [Abstract] [Full Text]

				G. M. Folger JR Pulmonary Vascular Disease in Children with Congenital Cardiovascular Malformations: Etiologic Considerations Angiology, December 1, 1983; 34(12): 784 - 811. [Abstract] [PDF]