Circulation, Vol 56, 66-71, Copyright © 1977 by American Heart Association
JL Ritchie, GB Trobaugh, GW Hamilton, KL Gould, KA Narahara, JA Murray and DL Williams
Myocardial imaging with intravenous thallium-201 (201Tl) was performed at
rest and following maximal treadmill exercise in 101 patients with
suspected coronary artery disease. Results were interpreted from Polaroid
scintiphotos by three independent observers with complete interobserver
agreement in 79%. Of 25 patients with no or insignificant coronary artery
disease (less than 50% diameter stenosis), one (4%) had a resting 201Tl
image defect, one (4%) had an exercise 201Tl defect, none had an ECG Q
wave, and four (16%) had exercise ST-segment depression. Among 76 patients
with coronary artery disease (greater than or equal to 50% diameter
stenosis), 58 (76%) had a defect on either the rest or exercise 201Tl
image. The proportion of patients with an exercise image defect (50/76,
66%) was greater than the proportion with exercise ST depression alone
(34/76, 45%; P less than 0.02). Overall, 69 of the 76 (91%) patients with
coronary artery disease had either a positive rest or exercise myocardial
image and/or a positive rest (ECG Q waves) or exercise (ST depression)
electrocardiogram. This exceeded the proportion with only rest or exercise
electrocardiographic abnormalities (50/76, 65%; P less than 0.001). We
conclude that rest and exercise myocardial imaging with 201Tl is easily
accomplished with readily available imaging equipment. The image data
enhanced the diagnostic sensitivity of stress electrocardiography, and
provided spatial identification of the abnormal segment(s) of myocardium.
ARTICLES
Myocardial imaging with thallium-201 at rest and during exercise. Comparison with coronary arteriography and resting and stress electrocardiography
This article has been cited by other articles:
 |
|
 |
|
  V. Voudris, D. Avramides, M. Koutelou, J. Malakos, A. Manginas, M. Papadakis, and D. V. Cokkinos Relative Coronary Flow Velocity Reserve Improves Correlation With Stress Myocardial Perfusion Imaging in Assessment of Coronary Artery Stenoses Chest, October 1, 2003; 124(4): 1266 - 1274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Wei, E. Le, J.-P. Bin, M. Coggins, A. R. Jayawera, and S. Kaul Mechanism of reversible 99mTc-sestamibi perfusion defects during pharmacologically induced vasodilatation Am J Physiol Heart Circ Physiol, April 1, 2001; 280(4): H1896 - H1904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tadamura, H. Iida, K. Matsumoto, M. Mamede, S. Kubo, H. Toyoda, T. Shiozaki, T. Mukai, Y. Magata, and J. Konishi Comparison of myocardial blood flow during dobutamine-atropine infusion with that after dipyridamole administration in normal men J. Am. Coll. Cardiol., January 1, 2001; 37(1): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. B. Y. Chiang, A. M. Roberts, A. M. Kashem, W. P. Santamore, S. Chien, L. Gray Jr, and R. Dowling Chemoreflexes: An Experimental Study Arch Surg, May 1, 2000; 135(5): 577 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Chatziioannou, W. H. Moore, P. V. Ford, R. E. Fisher, V.-V. Lee, C. Alfaro-Franco, and R. D. Dhekne Prognostic Value of Myocardial Perfusion Imaging in Patients With High Exercise Tolerance Circulation, February 23, 1999; 99(7): 867 - 872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Di Carli, J. Czernin, C. K. Hoh, V. H. Gerbaudo, R. C. Brunken, S.-C. Huang, M. E. Phelps, and H. R. Schelbert Relation Among Stenosis Severity, Myocardial Blood Flow, and Flow Reserve in Patients With Coronary Artery Disease Circulation, April 1, 1995; 91(7): 1944 - 1951. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Sekiya, M. Suzuki, Y. Fujiwara, T. Sumimoto, M. Hamada, and K. Hiwada Hemodynamic Characteristics of Patients with Coronary Artery Disease Presenting False-Negative Exercise Stress Test Angiology, June 1, 1992; 43(6): 506 - 511. [Abstract] [PDF]
|
|
|
|
 |
|
 T. S. Kotler and G. A. Diamond Exercise Thallium-201 Scintigraphy in the Diagnosis and Prognosis of Coronary Artery Disease Ann Intern Med, November 1, 1990; 113(9): 684 - 702. [Abstract] [PDF]
|
|
|
|
|
|
C. Chevreaud, P. Thouvenot, G. Lapeyre, M-H. Laurens, and C. Renard Thallium 201 Muscle Scintigraphy: Application to the Management of Patients with Arterial Occlusive Disease Angiology, April 1, 1987; 38(4): 309 - 314. [Abstract] [PDF]
|
|
|
|
 |
|
 J. M. Wahl, A-H. Hakki, and A. S. Iskandrian Prognostic Implications of Normal Exercise Thallium 201 Images Arch Intern Med, February 1, 1985; 145(2): 253 - 256. [Abstract] [PDF]
|
|
|
|
|
|
W. Shapiro, K. A. Narahara, and J. Park Improved Exercise Myocardial Perfusion During Lidoflazine Therapy Angiology, November 1, 1983; 34(11): 705 - 710. [Abstract] [PDF]
|
|
|
|
|
|
A. S. Iskandrian, W. Haaz, and B. L. Segal Exercise Thallium 201 Imaging Clinical Implications of Normal Exercise Images Arch Intern Med, March 1, 1981; 141(4): 501 - 503. [Abstract] [PDF]
|
|
|
|
|
|
J. J. Sampson Angina of Impending Myocardial Infarction: The Intermediate Syndrome Changing Concepts, Proposed Therapy, and Current Clues of Gravity Angiology, August 1, 1980; 31(8): 509 - 521. [PDF]
|
|
|
|
|
|
A. S. Iskandrian, L. Wasserman, and B. L. Segal Thallium 201 Myocardial Scintigraphy: Advantages and Limitations Arch Intern Med, March 1, 1980; 140(3): 320 - 327. [Abstract] [PDF]
|
|
|
|
|
|
E. H. Botvinick Myocardial Perfusion Scintigraphy Arch Intern Med, February 1, 1980; 140(2): 169 - 171. [Abstract] [PDF]
|
|
|
|
|
|
K. I. SHINE, J. K. PERLOFF, J. S. CHILD, R. C. MARSHALL, and H. SCHELBERT Noninvasive Assessment of Myocardial Function Ann Intern Med, January 1, 1980; 92(1): 78 - 90. [Abstract] [PDF]
|
|
|
|
|
|
M. B. Bodenheimer, V. S. Banka, C. M. Fooshee, and R. H. Helfant Extent and Severity of Coronary Heart Disease: Determinations by Thallous Chloride Tl 201 Myocardial Perfusion Scanning and Comparison With Stress Electrocardiography Arch Intern Med, June 1, 1979; 139(6): 630 - 634. [Abstract] [PDF]
|
|