Circulation, Vol 56, 366-374, Copyright © 1977 by American Heart Association
PB Oliva and JC Breckinridge
Coronary arteriography was performed before and after the intracoronary
injection of nitroglycerin to determine the presence or absence of spasm in
patients within the first 12 hours of acute myocardial infarction. Coronary
arterial spasm was demonstrated in six of fifteen (40%) acute myocardial
infarctions associated with coronary artery disease. In five of the six
instances the interval from the onset of symptoms to arteriography was less
than 6 hours. Spasm was superimposed on a high-grade atherosclerotic
obstruction and was separated from the catheter tip by a segment of normal
vessel in each instance. The coronary artery remained patent (following the
initial relief of spasm) in two patients maintained on sublingual nitrates
and heparin. Spasm, superimposed on an atherosclerotic obstruction, may be
the primary event or a secondary occurrence in the pathophysiology of acute
myocardial infarction. Catecholamines could play an important role in the
early pathophysiology of acute myocardial infarction by producing spasm
and/or platelet aggregation at the site of an atherosclerotic obstruction.
A dynamic interaction between spasm, platelet aggregates and the
atherosclerotic plaque may precede coronary thrombosis.
ARTICLES
Arteriographic evidence of coronary arterial spasm in acute myocardial infarction
This article has been cited by other articles:
 |
|
 |
|
  H. Saito, T. Itoh, M. Itoh, Y. Kanaya, T. Suzuki, and K. Hiramori Simultaneous Multivessel Coronary Spasm Causing Acute Myocardial Infarction: A Case Report Angiology, February 1, 2007; 58(1): 112 - 117. [Abstract] [PDF]
|
|
|
|
 |
|
 J. Steffel, A. Akhmedov, H. Greutert, T. F. Luscher, and F. C. Tanner Histamine Induces Tissue Factor Expression: Implications for Acute Coronary Syndromes Circulation, July 19, 2005; 112(3): 341 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Okumura, T. Osanai, T. Kosugi, H. Hanada, H. Ishizaka, T. Fukushi, T. Kamada, T. Miura, T. Hatayama, T. Nakano, et al. Enhanced phospholipase C activity in the cultured skin fibroblast obtained from patients with coronary spastic angina: possible role for enhanced vasoconstrictor response J. Am. Coll. Cardiol., November 15, 2000; 36(6): 1847 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Miwa, K. Nakagawa, N. Yoshida, Y. Taguchi, and H. Inoue Lipoprotein(a) is a risk factor for occurrence of acute myocardial infarction in patients with coronary vasospasm J. Am. Coll. Cardiol., April 1, 2000; 35(5): 1200 - 1205. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O Ueda, K Kohchi, Y Kishi, and F Numano Long lasting spasticity in controlled vasospastic angina Heart, May 1, 1999; 81(5): 528 - 532. [Abstract] [Full Text]
|
|
|
|
|
|
F. M. Sheridan, P. G. Cole, and D. Ramage Leukocyte Adhesion to the Coronary Microvasculature During Ischemia and Reperfusion in an In Vivo Canine Model Circulation, May 15, 1996; 93(10): 1784 - 1787. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. Zainea, W. F. C. Duvernoy, A. Chauhan, S. David, E. Soto, and D. Small Acute Myocardial Infarction in Angiographically Normal Coronary Arteries Following Induction of General Anesthesia Arch Intern Med, November 14, 1994; 154(21): 2495 - 2498. [Abstract] [PDF]
|
|
|
|
|
|
J. S. Alpert Myocardial Infarction With Angiographically Normal Coronary Arteries Arch Intern Med, February 14, 1994; 154(3): 265 - 269. [Abstract] [PDF]
|
|
|
|
|
|
R. N. A. Gasser The Interdependence of Hypertension, Calcium Overload, and Coronary Spasm in the Development of Myocardial Infarction Angiology, August 1, 1988; 39(8): 761 - 772. [Abstract] [PDF]
|
|
|
|
 |
|
 W. B. Kannel, P. A. Wolf, W. P. Castelli, and R. B. D'Agostino Fibrinogen and Risk of Cardiovascular Disease: The Framingham Study JAMA, September 4, 1987; 258(9): 1183 - 1186. [Abstract] [PDF]
|
|
|
|
 |
|
 D. H. SPODICK Inflammation and the Onset of Myocardial Infarction Ann Intern Med, May 1, 1985; 102(5): 699 - 702. [Abstract] [PDF]
|
|
|
|
|
|
L. Dumont, J. LeLorier, P. Stanley, and C. Chartrand Effect of Nitroglycerin on Regional Myocardial Blood Flow Following an Experimental Coronary Spasm Angiology, September 1, 1984; 35(9): 553 - 559. [Abstract] [PDF]
|
|
|
|
|
|
S. Lamme, B.W. Johansson, and S.E. Lindell Peripheral Atherosclerosis in Patients with Myocardial Infarction Angiology, June 1, 1984; 35(6): 373 - 379. [Abstract] [PDF]
|
|
|
|
|
|
S. Omote, H. Yasue, A. Takizawa, M. Nagao, H. Hyon, S. Nishida, and M. Horie Coronary Arteriographic Findings During Early Hours of Acute Myocardial Infarction: Response to Intracoronary Injection of Nitrates Angiology, August 1, 1983; 34(8): 553 - 560. [Abstract] [PDF]
|
|
|
|
|
|
N. L. DePace, I. M. Herling, M. N. Kotler, A-H. Hakki, S. R. Spielman, and B. L. Segal Intravenous Nitroglycerin for Rest Angina: Potential Pathophysiologic Mechanisms of Action Arch Intern Med, October 1, 1982; 142(10): 1806 - 1809. [Abstract] [PDF]
|
|
|
|
|
|
T. T. Bashour, O. Hakim, A. L. Ennis, and T. O. Cheng Coronary Artery Spasm With Sinus Node Dysfunction and Syncope Arch Intern Med, September 1, 1982; 142(9): 1719 - 1721. [Abstract] [PDF]
|
|
|
|
|
|
G. Brevetti, M. Chiariello, G. P. Ferulano, S. Betocchi, G. Paudice, G. Lavecchia, S. Abate, S. Verrienti, and M. Condorelli Propranolol-induced Reverse Vascular Steal in Arteriopathic Patients Angiology, February 1, 1982; 33(2): 78 - 89. [Abstract] [PDF]
|
|
|
|
|
|
M. H. Luria, M. W. Johnson, R. Pego, C. A. Seuc, S. J. Manubens, M. R. Wieland, and R. G. Wieland Relationship Between Sex Hormones, Myocardial Infarction, and Occlusive Coronary Disease Arch Intern Med, January 1, 1982; 142(1): 42 - 44. [Abstract] [PDF]
|
|
|
|
|
|
R. E. RUDE, J. E. MULLER, and B. EUGENE Efforts to Limit the Size of Myocardial Infarcts Ann Intern Med, December 1, 1981; 95(6): 736 - 761. [Abstract] [PDF]
|
|
|
|
|
|
E. Braunwald Coronary Artery Spasm: Mechanisms and Clinical Relevance JAMA, October 23, 1981; 246(17): 1957 - 1959. [Abstract] [PDF]
|
|
|
|
|
|
R. J. LUCHI and R. A. CHAHINE Coronary Artery Spasm, Coronary Artery Thrombosis, and Myocardial Infarction Ann Intern Med, October 1, 1981; 95(4): 502 - 505. [Abstract] [PDF]
|
|
|
|
 |
|
 F. W. Schoonmaker Percutaneous Preformed Single Catheter Coronary Arteriography and Its Complications: 12,500 Patients Vascular and Endovascular Surgery, July 1, 1981; 15(4): 258 - 265. [PDF]
|
|
|
|
|
|
H. Yasue, Shingo, Omote, A. Takizawa, and M. Nagao Acute Myocardial Infarction Induced by Ergotamine Tartrate: Possible Role of Coronary Arterial Spasm Angiology, June 1, 1981; 32(6): 414 - 418. [Abstract] [PDF]
|
|
|
|
|
|
B. G. Brown Coronary Vasospasm: Observations Linking the Clinical Spectrum of Ischemic Heart Disease to the Dynamic Pathology of Coronary Atherosclerosis Arch Intern Med, May 1, 1981; 141(6): 716 - 722. [Abstract] [PDF]
|
|
|
|
|
|
P. B. OLIVA Pathophysiology of Acute Myocardial Infarction, 1981 Ann Intern Med, February 1, 1981; 94(2): 236 - 250. [Abstract] [PDF]
|
|
|
|
|
|
R. K. Mautner and T. D. Giles Coronary Artery Spasm Arch Intern Med, July 1, 1980; 140(7): 979 - 980. [Abstract] [PDF]
|
|
|
|
|
|
J. L. Gerry, S. C. Achuff, L. C. Becker, M. S. Pond, and H. L. Greene Predictability of the Response to the Ergonovine Test: Value in the Diagnosis of Coronary Spasm JAMA, December 28, 1979; 242(26): 2858 - 2861. [Abstract] [PDF]
|
|
|
|
|
|
R. J. LUCHI, R. A. CHAHINE, and A. E. RAIZNER Coronary Artery Spasm Ann Intern Med, September 1, 1979; 91(3): 441 - 449. [Abstract] [PDF]
|
|
|
|
|
|
P. B. OLIVA, A. HILGENBERG, and D. MCELROY Obstruction of the Proximal Right Coronary Artery with Acute Inferior Infarction Due to Blunt Chest Trauma Ann Intern Med, August 1, 1979; 91(2): 205 - 207. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Chahine Prinzmetal's Variant Angina: A Syndrome Apart or Another Clinical Presentation of Atheromatous Heart Disease Arch Intern Med, January 1, 1979; 139(1): 26 - 27. [Abstract] [PDF]
|
|
|
|
|
|
M. KARMAZYN and D. F. HORROBIN Coronary Artery Disease and Progesterone Ann Intern Med, November 1, 1978; 89(5_Part_1): 724 - 724. [Abstract] [PDF]
|
|
|
|
|
|
T. Nakano, T. Osanai, H. Tomita, M. Sekimata, Y. Homma, and K. Okumura Enhanced Activity of Variant Phospholipase C-{delta}1 Protein (R257H) Detected in Patients With Coronary Artery Spasm Circulation, April 30, 2002; 105(17): 2024 - 2029. [Abstract] [Full Text] [PDF]
|
|