Circulation, Vol 56, 875-883, Copyright © 1977 by American Heart Association
AM Gotto, GA Gorry, JR Thompson, JS Cole, R Trost, D Yeshurun and ME DeBakey
The relationship between fasting plasma cholesterol and triglyceride
concentrations and the frequency and extensiveness of coronary artery
disease (CAD) was studied in 496 subjects evaluated for chest pain by
coronary arteriography at The Methodist Hospital. One hundred six of the
patients had no CAD while 390 had 25% or greater stenosis of one or more
major vessels. Ninety-one percent had 75% or greater stenosis of at least
one major vessel. Mean age for the group with CAD was 55.7 +/- 8.7 and
without disease 49.4 +/- 11.6 (P less than 0.01). Both cholesterol and
triglyceride concentrations were higher (P less than 0.001) in the group
with CAD. Mean cholesterol concentration in males increased from 195 +/- 36
mg/dl in the group without CAD to 219 +/- 41 in the group with three vessel
disease and in females from 207 +/- 40 to 252 +/- 42. A progressive
increase in triglyceride values was also detected but was less consistent.
At the level of 25% and greater obstruction, the partial correlation
coefficients between the number of vessels involved and the cholesterol and
triglyceride concentrations, respectively, were +0.201 and +0.181.
ARTICLES
Relationship between plasma lipid concentrations and coronary artery disease in 496 patients
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